C5orf42

Entrez Summary: N/A
UniProt Summary: Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000305|PubMed:25877302}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein localization to ciliary transition zone
establishment of planar polarity
establishment of tissue polarity
ciliary transition zone
morphogenesis of a polarized epithelium
coronary vasculature development
protein localization to cilium
embryonic digit morphogenesis
ventricular septum development
roof of mouth development
cerebellum development
cardiac septum development
metencephalon development
embryonic appendage morphogenesis
embryonic limb morphogenesis
cardiac ventricle development
appendage morphogenesis
limb morphogenesis
hindbrain development
cardiac chamber development
appendage development
limb development
kidney development
renal system development
urogenital system development
cilium assembly
cilium organization
morphogenesis of an epithelium
plasma membrane bounded cell projection assembly
cell projection assembly
blood vessel development
vasculature development
cardiovascular system development
heart development
tissue morphogenesis
embryonic morphogenesis
protein localization to organelle
brain development
organelle assembly
head development