C9orf78 [The Human Chemical-Genetic Interaction Map Project]

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======= C9orf78 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C9orf78
  * **<color #00a2e8>Official Name</color>**: chromosome 9 open reading frame 78
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51759|51759]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ63|Q9NZ63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C9orf78&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C9orf78|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619569|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. {ECO:0000250|UniProtKB:Q10148}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hep 59|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of mRNA metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.74|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.76|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.79|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.8|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.82|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.85|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.85|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.86|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.92|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.96|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.05|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.16|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.25|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.26|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.27|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppih|PPIH]]|0.467|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.461|
|[[:human genes:a:arid4b|ARID4B]]|0.426|
|[[:human genes:w:wbp11|WBP11]]|0.425|
|[[:human genes:d:dazap1|DAZAP1]]|0.416|
|[[:human genes:e:eif4a1|EIF4A1]]|0.413|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.412|
|[[:human genes:c:ccnl1|CCNL1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|2/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|9/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 853
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C9orf78 Expression in NALM6 Cells: 9.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>