C9orf78

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. {ECO:0000250|UniProtKB:Q10148}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Erlotinib 10μM R05 exp216	1.74
Cincreasin 100μM R08 exp473	1.76
LB-100 4.1μM R02 exp72	1.79
Aminopterin 0.005μM R07 exp335	1.8
Tozasertib 0.1μM R07 exp414	1.82
Ethanol 0.01 R05 exp234	1.85
Lead acetate 2000μM R08 exp498 no dilution day6	1.85
MK2206 4μM R08 exp504	1.86
Arsenic trioxide 60μM R08 exp449	1.92
Rapamycin 10μM R00 exp30	1.96
GSK626616 14μM R08 exp485	2.05
Lead acetate 2000μM R08 exp497	2.16
Artemisinin 50μM R08 exp450	2.25
CB-5083 0.4μM R08 exp468	2.26
Pyridostatin 4μM R05 exp240	2.27
Latrunculin-B 10μM R07 exp374	2.43

Global Fraction of Cell Lines Where Essential: 38/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	2/26
breast	3/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	1/20
lung	9/75
lymphocyte	1/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

spliceosomal complex
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
regulation of mRNA metabolic process