CA9

Entrez Summary: N/A
UniProt Summary: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. {ECO:0000269|PubMed:18703501}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-2.08
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.91

carbonate dehydratase activity
microvillus membrane
response to testosterone
bicarbonate transport
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to hypoxia
response to ketone
basolateral plasma membrane
cellular response to decreased oxygen levels
cellular response to oxygen levels
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
morphogenesis of an epithelium
organic anion transport
tissue morphogenesis
anion transport
zinc ion binding
response to lipid
nucleolus
response to hormone
response to organic cyclic compound
response to drug
epithelium development
secretion
response to abiotic stimulus
ion transport
response to endogenous stimulus
response to oxygen-containing compound
cellular response to stress
tissue development