CABLES1 [The Human Chemical-Genetic Interaction Map Project]

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======= CABLES1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CABLES1
  * **<color #00a2e8>Official Name</color>**: Cdk5 and Abl enzyme substrate 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91768|91768]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDN4|Q8TDN4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CABLES1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CABLES1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell division|
|regulation of cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.29|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.89|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.87|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.86|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.77|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.75|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.81|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.86|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.91|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.02|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.14|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10106
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CABLES1 Expression in NALM6 Cells: 2.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>