CABLES1

Entrez Summary: N/A
UniProt Summary: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1.5μM R08 exp441	-2.29
FTY720 3μM R08 exp483	-1.89
CyclicAMP 200μM R08 exp475	-1.87
Isonicotinamide 500μM R03 exp129	-1.86
EPZ-5676 30μM R05 exp233	-1.77
Disulfiram 4.3μM R06 exp281	-1.75
Wortmannin 5μM R00 exp38	1.81
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.86
YM155 0.0002μM R01 exp61	1.91
Hydroxyurea 100μM R07 exp329	2.02
Taxol 0.002μM R01 exp54	2.14
ABT-702 0.1μM R06 exp260	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution