CACNA1C

Gene Information

Official Symbol: CACNA1C
Official Name: calcium voltage-gated channel subunit alpha1 C
Aliases and Previous Symbols: N/A
Entrez ID: 775
UniProt: Q13936
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4694
Expression level (log2 read counts): -0.55

Expression Distribution

Ion trans
Ca chan IQ
PKD channel

calcium ion transmembrane transport via high voltage-gated calcium channel
voltage-gated calcium channel activity involved in AV node cell action potential
membrane depolarization during atrial cardiac muscle cell action potential
calcium-mediated signaling using extracellular calcium source
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
membrane depolarization during AV node cell action potential
AV node cell to bundle of His cell signaling
AV node cell action potential
positive regulation of adenylate cyclase activity
high voltage-gated calcium channel activity
AV node cell to bundle of His cell communication
L-type voltage-gated calcium channel complex
atrial cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell signaling
regulation of ventricular cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell communication
cell communication by electrical coupling involved in cardiac conduction
membrane depolarization during cardiac muscle cell action potential
alpha-actinin binding
cell communication by electrical coupling
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
positive regulation of cyclase activity
positive regulation of lyase activity
regulation of cardiac muscle contraction by calcium ion signaling
voltage-gated calcium channel complex
cell-cell signaling involved in cardiac conduction
regulation of adenylate cyclase activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle cell action potential
membrane depolarization during action potential
embryonic forelimb morphogenesis
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell contraction
cardiac muscle cell action potential involved in contraction
voltage-gated calcium channel activity
forelimb morphogenesis
cardiac muscle cell contraction
regulation of actin filament-based movement
regulation of cyclase activity
calcium ion import