CACNA2D4

Official Symbol: CACNA2D4
Official Name: calcium voltage-gated channel auxiliary subunit alpha2delta 4
Aliases and Previous Symbols: N/A
Entrez ID: 93589
UniProt: Q7Z3S7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

detection of light stimulus involved in visual perception
detection of light stimulus involved in sensory perception
voltage-gated calcium channel complex
voltage-gated calcium channel activity
detection of visible light
detection of light stimulus
cardiac conduction
detection of external stimulus
detection of abiotic stimulus
multicellular organismal signaling
calcium ion transmembrane transport
visual perception
sensory perception of light stimulus
regulation of heart contraction
calcium ion transport
regulation of blood circulation
divalent metal ion transport
divalent inorganic cation transport
response to light stimulus
response to radiation
regulation of ion transmembrane transport
detection of stimulus involved in sensory perception
inorganic cation transmembrane transport
regulation of transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
detection of stimulus
regulation of ion transport
cation transport
ion transmembrane transport
sensory perception
response to abiotic stimulus
transmembrane transport
ion transport
nervous system process
regulation of transport
system process