CACNG4

Gene Information

Official Symbol: CACNG4
Official Name: calcium voltage-gated channel auxiliary subunit gamma 4
Aliases and Previous Symbols: N/A
Entrez ID: 27092
UniProt: Q9UBN1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:21172611}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9295
Expression level (log2 read counts): -6.6

Expression Distribution

neurotransmitter receptor transport, postsynaptic endosome to lysosome
positive regulation of AMPA receptor activity
channel regulator activity
postsynaptic neurotransmitter receptor diffusion trapping
receptor diffusion trapping
neurotransmitter receptor diffusion trapping
L-type voltage-gated calcium channel complex
regulation of postsynaptic neurotransmitter receptor activity
somatodendritic compartment
protein localization to postsynaptic specialization membrane
neurotransmitter receptor internalization
neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of glutamate receptor signaling pathway
postsynaptic density membrane
regulation of AMPA receptor activity
AMPA glutamate receptor complex
positive regulation of synaptic transmission, glutamatergic
ionotropic glutamate receptor binding
protein localization to postsynaptic membrane
positive regulation of signaling receptor activity
neurotransmitter receptor transport
calcium channel regulator activity
protein localization to lysosome
voltage-gated calcium channel activity
receptor localization to synapse
establishment of protein localization to vacuole
regulation of postsynaptic membrane neurotransmitter receptor levels
integral component of postsynaptic density membrane
membrane depolarization
response to cocaine
transmission of nerve impulse
protein localization to vacuole
receptor internalization
protein localization to synapse
regulation of glutamate receptor signaling pathway
endocytic vesicle membrane
positive regulation of cation channel activity
regulation of synaptic transmission, glutamatergic
cell body
regulation of neurotransmitter receptor activity