CACNG7

Gene Information

Official Symbol: CACNG7
Official Name: calcium voltage-gated channel auxiliary subunit gamma 7
Aliases and Previous Symbols: N/A
Entrez ID: 59284
UniProt: P62955
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:21172611}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11120
Expression level (log2 read counts): -5.01

Expression Distribution

cerebellar mossy fiber
neurotransmitter receptor transport, postsynaptic endosome to lysosome
channel regulator activity
postsynaptic neurotransmitter receptor diffusion trapping
receptor diffusion trapping
neurotransmitter receptor diffusion trapping
L-type voltage-gated calcium channel complex
protein localization to postsynaptic specialization membrane
neurotransmitter receptor internalization
neurotransmitter receptor localization to postsynaptic specialization membrane
postsynaptic density membrane
positive regulation of dendrite extension
regulation of dendrite extension
regulation of AMPA receptor activity
AMPA glutamate receptor complex
voltage-gated calcium channel complex
positive regulation of synaptic transmission, glutamatergic
neurotransmitter receptor transport
protein localization to postsynaptic membrane
calcium channel regulator activity
protein localization to lysosome
voltage-gated calcium channel activity
receptor localization to synapse
establishment of protein localization to vacuole
regulation of postsynaptic membrane neurotransmitter receptor levels
integral component of postsynaptic density membrane
transmission of nerve impulse
protein localization to vacuole
receptor internalization
protein localization to synapse
regulation of glutamate receptor signaling pathway
regulation of synaptic transmission, glutamatergic
regulation of neurotransmitter receptor activity
localization within membrane
cardiac conduction
receptor metabolic process
lysosomal transport
multicellular organismal signaling
vacuolar transport
positive regulation of synaptic transmission