CACUL1

Entrez Summary: N/A
UniProt Summary: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. {ECO:0000269|PubMed:19829063}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mubritinib 0.2μM R01 exp48	-2.05
Genistein 15μM R07 exp360	-1.84

G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
mitotic cell cycle phase transition
cell cycle phase transition
ubiquitin protein ligase binding
protein kinase binding
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
positive regulation of protein kinase activity
modification-dependent macromolecule catabolic process
positive regulation of kinase activity
proteolysis involved in cellular protein catabolic process
mitotic cell cycle process
cellular protein catabolic process
positive regulation of transferase activity
mitotic cell cycle
protein catabolic process
regulation of protein kinase activity
regulation of kinase activity
cellular macromolecule catabolic process
positive regulation of cell population proliferation
regulation of transferase activity
cell cycle process
positive regulation of protein phosphorylation
macromolecule catabolic process
positive regulation of phosphorylation
organonitrogen compound catabolic process
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
proteolysis
cell cycle
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of protein metabolic process
organic substance catabolic process
positive regulation of molecular function