CADM4

Gene Information

Official Symbol: CADM4
Official Name: cell adhesion molecule 4
Aliases and Previous Symbols: N/A
Entrez ID: 199731
UniProt: Q8NFZ8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity. {ECO:0000269|PubMed:16261159}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4506
Expression level (log2 read counts): 2.5

Expression Distribution

I-set
C2-set 2
ig
V-set

vascular endothelial growth factor receptor 1 binding
vascular endothelial growth factor receptor 2 binding
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of cellular response to vascular endothelial growth factor stimulus
negative regulation of vascular endothelial growth factor receptor signaling pathway
regulation of Rac protein signal transduction
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
negative regulation of peptidyl-threonine phosphorylation
cell-cell contact zone
regulation of vascular endothelial growth factor receptor signaling pathway
cell leading edge
regulation of peptidyl-threonine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
receptor tyrosine kinase binding
protein phosphatase binding
regulation of wound healing
negative regulation of cellular response to growth factor stimulus
regulation of response to wounding
regulation of Ras protein signal transduction
regulation of peptidyl-tyrosine phosphorylation
regulation of cellular response to growth factor stimulus
regulation of small GTPase mediated signal transduction
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of cell motility
cell adhesion
biological adhesion
regulation of locomotion
regulation of cellular component movement
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of response to stress