CALB1 [The Human Chemical-Genetic Interaction Map Project]

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======= CALB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CALB1
  * **<color #00a2e8>Official Name</color>**: calbindin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=793|793]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05937|P05937]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CALB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CALB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114050|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration|
|metanephric connecting tubule development|
|connecting tubule development|
|calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration|
|metanephric part of ureteric bud development|
|distal convoluted tubule development|
|metanephric distal convoluted tubule development|
|vitamin D binding|
|metanephric distal tubule development|
|metanephric collecting duct development|
|short-term memory|
|cuticular plate|
|regulation of postsynaptic cytosolic calcium ion concentration|
|distal tubule development|
|collecting duct development|
|presynaptic cytosol|
|metanephric nephron tubule development|
|metanephric nephron epithelium development|
|regulation of presynaptic cytosolic calcium ion concentration|
|postsynaptic cytosol|
|metanephric tubule development|
|metanephric epithelium development|
|retina layer formation|
|calyx of Held|
|metanephros morphogenesis|
|long-term memory|
|stereocilium|
|hippocampal mossy fiber to CA3 synapse|
|neuron cellular homeostasis|
|regulation of long-term synaptic potentiation|
|retina morphogenesis in camera-type eye|
|cochlea development|
|neural retina development|
|GABA-ergic synapse|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|mesonephros development|
|nephron epithelium development|
|camera-type eye morphogenesis|
|memory|
|nephron development|
|kidney epithelium development|
|retina development in camera-type eye|
|eye morphogenesis|
|dendritic spine|
|regulation of synaptic plasticity|
|inner ear development|
|locomotory behavior|
|ear development|
|sensory organ morphogenesis|
|learning or memory|
|kidney development|
|synapse|
|renal system development|
|axon|
|cognition|
|camera-type eye development|
|urogenital system development|
|neuron projection|
|regulation of cytosolic calcium ion concentration|
|anatomical structure homeostasis|
|glutamatergic synapse|
|eye development|
|visual system development|
|sensory system development|
|neuronal cell body|
|dendrite|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|sensory organ development|
|cellular metal ion homeostasis|
|behavior|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|ion homeostasis|
|zinc ion binding|
|tube development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|animal organ morphogenesis|
|chemical homeostasis|
|epithelium development|
|nervous system process|
|homeostatic process|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.92|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.92|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.82|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.75|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.7|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15894
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CALB1 Expression in NALM6 Cells: 2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>