CALB1
Gene Information
- Official Symbol: CALB1
- Official Name: calbindin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 793
- UniProt: P05937
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Pfam Domains GO Terms
Pfam Domains
| efhand |
GO Terms
| calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration |
| metanephric connecting tubule development |
| connecting tubule development |
| calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration |
| metanephric part of ureteric bud development |
| distal convoluted tubule development |
| metanephric distal convoluted tubule development |
| vitamin D binding |
| metanephric distal tubule development |
| metanephric collecting duct development |
| short-term memory |
| cuticular plate |
| regulation of postsynaptic cytosolic calcium ion concentration |
| distal tubule development |
| collecting duct development |
| presynaptic cytosol |
| metanephric nephron tubule development |
| metanephric nephron epithelium development |
| regulation of presynaptic cytosolic calcium ion concentration |
| postsynaptic cytosol |
| metanephric tubule development |
| metanephric epithelium development |
| retina layer formation |
| calyx of Held |
| metanephros morphogenesis |
| long-term memory |
| stereocilium |
| hippocampal mossy fiber to CA3 synapse |
| neuron cellular homeostasis |
| regulation of long-term synaptic potentiation |
| retina morphogenesis in camera-type eye |
| cochlea development |
| neural retina development |
| GABA-ergic synapse |
| nephron tubule development |
| renal tubule development |
| metanephros development |
| kidney morphogenesis |
| ureteric bud development |
| mesonephric epithelium development |
| mesonephric tubule development |
| mesonephros development |
| nephron epithelium development |
| camera-type eye morphogenesis |
| memory |
| nephron development |
| kidney epithelium development |
| retina development in camera-type eye |
| eye morphogenesis |
| dendritic spine |
| regulation of synaptic plasticity |
| inner ear development |
| locomotory behavior |
| ear development |
| sensory organ morphogenesis |
| learning or memory |
| kidney development |
| synapse |
| renal system development |
| axon |
| cognition |
| camera-type eye development |
| urogenital system development |
| neuron projection |
| regulation of cytosolic calcium ion concentration |
| anatomical structure homeostasis |
| glutamatergic synapse |
| eye development |
| visual system development |
| sensory system development |
| neuronal cell body |
| dendrite |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| sensory organ development |
| cellular metal ion homeostasis |
| behavior |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| cellular chemical homeostasis |
| ion homeostasis |
| zinc ion binding |
| tube development |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| animal organ morphogenesis |
| chemical homeostasis |
| epithelium development |
| nervous system process |
| homeostatic process |
| tissue development |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Alda-1 10μM R06 exp262 | -1.92 |
| THZ1 0.06μM R08 exp531 | -1.92 |
| A-769662 20μM R07 exp331 | -1.82 |
| Milciclib 2μM R08 exp502 | -1.75 |
| Cabazitaxel 0.001μM R05 exp223 | 1.7 |
| L-BMAA 500 to 750μM on day4 R04 exp185 | 1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15894
- Expression level (log2 read counts): 2.21
Expression Distribution
CALB1 Expression in NALM6 Cells: 2.21
