CALCA

Entrez Summary: This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcitonin receptor binding
negative regulation of bone resorption
negative regulation of bone remodeling
negative regulation of tissue remodeling
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
embryo implantation
regulation of bone resorption
monocyte chemotaxis
mononuclear cell migration
regulation of bone remodeling
regulation of tissue remodeling
cell
phospholipase C-activating G protein-coupled receptor signaling pathway
hormone activity
adenylate cyclase-activating G protein-coupled receptor signaling pathway
myeloid leukocyte migration
leukocyte chemotaxis
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
female pregnancy
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell chemotaxis
multi-multicellular organism process
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
activation of protein kinase activity
second-messenger-mediated signaling
leukocyte migration
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
positive regulation of protein kinase activity
chemotaxis
taxis
cellular metal ion homeostasis
positive regulation of kinase activity
metal ion homeostasis
cellular cation homeostasis