CALM3 [The Human Chemical-Genetic Interaction Map Project]

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======= CALM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CALM3
  * **<color #00a2e8>Official Name</color>**: calmodulin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=808|808]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DP25|P0DP25]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CALM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CALM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114183|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. {ECO:0000250|UniProtKB:P0DP23, ECO:0000269|PubMed:16760425}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand Ca insen|
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 3 metabotropic glutamate receptor binding|
|positive regulation by organism of signal transduction in other organism involved in symbiotic interaction|
|N-terminal myristoylation domain binding|
|modulation by host of symbiont signal transduction pathway|
|positive regulation of signal transduction in other organism|
|positive regulation by host of symbiont cAMP-mediated signal transduction|
|modulation by host of symbiont cAMP-mediated signal transduction|
|positive regulation by host of symbiont signal transduction pathway|
|modulation of signal transduction in other organism involved in symbiotic interaction|
|positive regulation of cyclic-nucleotide phosphodiesterase activity|
|adenylate cyclase activator activity|
|modulation of signal transduction in other organism|
|nitric-oxide synthase regulator activity|
|positive regulation of ryanodine-sensitive calcium-release channel activity|
|catalytic complex|
|regulation of cell communication by electrical coupling involved in cardiac conduction|
|regulation of cyclic-nucleotide phosphodiesterase activity|
|protein phosphatase activator activity|
|regulation of cell communication by electrical coupling|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|adenylate cyclase binding|
|detection of calcium ion|
|nitric-oxide synthase binding|
|negative regulation of release of sequestered calcium ion into cytosol|
|titin binding|
|regulation of high voltage-gated calcium channel activity|
|regulation of synaptic vesicle endocytosis|
|positive regulation of sequestering of calcium ion|
|establishment of protein localization to mitochondrial membrane|
|negative regulation of peptidyl-threonine phosphorylation|
|negative regulation of calcium ion transport into cytosol|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|positive regulation of nitric-oxide synthase activity|
|response to corticosterone|
|phosphatidylinositol 3-kinase binding|
|positive regulation of phosphoprotein phosphatase activity|
|positive regulation of cAMP-mediated signaling|
|calcium channel complex|
|regulation of synaptic vesicle recycling|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of ryanodine-sensitive calcium-release channel activity|
|positive regulation of protein autophosphorylation|
|positive regulation of monooxygenase activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|protein serine/threonine kinase activator activity|
|positive regulation of peptidyl-threonine phosphorylation|
|negative regulation of calcium-mediated signaling|
|myelin sheath|
|response to mineralocorticoid|
|response to amphetamine|
|disordered domain specific binding|
|positive regulation of phosphatase activity|
|regulation of voltage-gated calcium channel activity|
|negative regulation of calcium ion transmembrane transporter activity|
|spindle microtubule|
|negative regulation of calcium ion transmembrane transport|
|activation of adenylate cyclase activity|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|negative regulation of cation channel activity|
|substantia nigra development|
|positive regulation of calcium-mediated signaling|
|regulation of nitric-oxide synthase activity|
|positive regulation of protein dephosphorylation|
|regulation of peptidyl-threonine phosphorylation|
|response to amine|
|regulation of protein autophosphorylation|
|regulation of cAMP-mediated signaling|
|sarcomere|
|response to bronchodilator|
|positive regulation of oxidoreductase activity|
|positive regulation of calcium ion transport into cytosol|
|regulation of monooxygenase activity|
|positive regulation of DNA binding|
|positive regulation of dephosphorylation|
|negative regulation of calcium ion transport|
|calcium-dependent protein binding|
|neural nucleus development|
|synaptic vesicle membrane|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|establishment of protein localization to mitochondrion|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|regulation of cardiac muscle contraction|
|protein localization to mitochondrion|
|regulation of synaptic vesicle exocytosis|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|voltage-gated potassium channel complex|
|midbrain development|
|regulation of calcium ion transmembrane transporter activity|
|regulation of cytokinesis|
|regulation of striated muscle contraction|
|regulation of oxidoreductase activity|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|regulation of heart rate|
|regulation of calcium ion transport into cytosol|
|mitochondrial membrane|
|positive regulation of ion transmembrane transporter activity|
|regulation of neurotransmitter secretion|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|positive regulation of transporter activity|
|regulation of synaptic vesicle cycle|
|negative regulation of transmembrane transport|
|regulation of phosphoprotein phosphatase activity|
|positive regulation of calcium ion transport|
|spindle pole|
|regulation of sequestering of calcium ion|
|regulation of DNA binding|
|ion channel binding|
|mitochondrial membrane organization|
|growth cone|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|regulation of protein dephosphorylation|
|vesicle|
|positive regulation of cation transmembrane transport|
|regulation of neurotransmitter transport|
|response to glucocorticoid|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|response to calcium ion|
|positive regulation of ion transmembrane transport|
|modification of morphology or physiology of other organism|
|regulation of muscle contraction|
|response to corticosteroid|
|regulation of regulated secretory pathway|
|regulation of cell division|
|regulation of cation channel activity|
|regulation of phosphatase activity|
|positive regulation of binding|
|response to ketone|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|regulation of dephosphorylation|
|regulation of exocytosis|
|response to alcohol|
|regulation of muscle system process|
|regulation of heart contraction|
|protein domain specific binding|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|establishment of protein localization to membrane|
|regulation of transmembrane transporter activity|
|mitotic cell cycle phase transition|
|positive regulation of ion transport|
|regulation of transporter activity|
|cell cycle phase transition|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|response to xenobiotic stimulus|
|response to steroid hormone|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of neurotransmitter levels|
|response to metal ion|
|regulation of binding|
|regulation of metal ion transport|
|negative regulation of protein phosphorylation|
|establishment of protein localization to organelle|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|mitochondrion organization|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|centrosome|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|detection of chemical stimulus|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|mitotic cell cycle process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|mitotic cell cycle|
|detection of stimulus|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|protein localization to organelle|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|response to lipid|
|membrane organization|
|regulation of kinase activity|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.11|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.79|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.72|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.83|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.9|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.9|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.92|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CALM3 Expression in NALM6 Cells: 8.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>