CALM3
Gene Information
- Official Symbol: CALM3
- Official Name: calmodulin 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 808
- UniProt: P0DP25
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016].
- UniProt Summary: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. {ECO:0000250|UniProtKB:P0DP23, ECO:0000269|PubMed:16760425}.
Pfam Domains GO Terms
Pfam Domains
| efhand Ca insen |
| efhand |
GO Terms
| type 3 metabotropic glutamate receptor binding |
| positive regulation by organism of signal transduction in other organism involved in symbiotic interaction |
| N-terminal myristoylation domain binding |
| modulation by host of symbiont signal transduction pathway |
| positive regulation of signal transduction in other organism |
| positive regulation by host of symbiont cAMP-mediated signal transduction |
| modulation by host of symbiont cAMP-mediated signal transduction |
| positive regulation by host of symbiont signal transduction pathway |
| modulation of signal transduction in other organism involved in symbiotic interaction |
| positive regulation of cyclic-nucleotide phosphodiesterase activity |
| adenylate cyclase activator activity |
| modulation of signal transduction in other organism |
| nitric-oxide synthase regulator activity |
| positive regulation of ryanodine-sensitive calcium-release channel activity |
| catalytic complex |
| regulation of cell communication by electrical coupling involved in cardiac conduction |
| regulation of cyclic-nucleotide phosphodiesterase activity |
| protein phosphatase activator activity |
| regulation of cell communication by electrical coupling |
| negative regulation of ryanodine-sensitive calcium-release channel activity |
| adenylate cyclase binding |
| detection of calcium ion |
| nitric-oxide synthase binding |
| negative regulation of release of sequestered calcium ion into cytosol |
| titin binding |
| regulation of high voltage-gated calcium channel activity |
| regulation of synaptic vesicle endocytosis |
| positive regulation of sequestering of calcium ion |
| establishment of protein localization to mitochondrial membrane |
| negative regulation of peptidyl-threonine phosphorylation |
| negative regulation of calcium ion transport into cytosol |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| positive regulation of nitric-oxide synthase activity |
| response to corticosterone |
| phosphatidylinositol 3-kinase binding |
| positive regulation of phosphoprotein phosphatase activity |
| positive regulation of cAMP-mediated signaling |
| calcium channel complex |
| regulation of synaptic vesicle recycling |
| regulation of cardiac muscle contraction by calcium ion signaling |
| regulation of ryanodine-sensitive calcium-release channel activity |
| positive regulation of protein autophosphorylation |
| positive regulation of monooxygenase activity |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| protein serine/threonine kinase activator activity |
| positive regulation of peptidyl-threonine phosphorylation |
| negative regulation of calcium-mediated signaling |
| myelin sheath |
| response to mineralocorticoid |
| response to amphetamine |
| disordered domain specific binding |
| positive regulation of phosphatase activity |
| regulation of voltage-gated calcium channel activity |
| negative regulation of calcium ion transmembrane transporter activity |
| spindle microtubule |
| negative regulation of calcium ion transmembrane transport |
| activation of adenylate cyclase activity |
| positive regulation of calcium ion transmembrane transporter activity |
| positive regulation of release of sequestered calcium ion into cytosol |
| negative regulation of cation channel activity |
| substantia nigra development |
| positive regulation of calcium-mediated signaling |
| regulation of nitric-oxide synthase activity |
| positive regulation of protein dephosphorylation |
| regulation of peptidyl-threonine phosphorylation |
| response to amine |
| regulation of protein autophosphorylation |
| regulation of cAMP-mediated signaling |
| sarcomere |
| response to bronchodilator |
| positive regulation of oxidoreductase activity |
| positive regulation of calcium ion transport into cytosol |
| regulation of monooxygenase activity |
| positive regulation of DNA binding |
| positive regulation of dephosphorylation |
| negative regulation of calcium ion transport |
| calcium-dependent protein binding |
| neural nucleus development |
| synaptic vesicle membrane |
| regulation of cardiac conduction |
| positive regulation of cation channel activity |
| establishment of protein localization to mitochondrion |
| positive regulation of calcium ion transmembrane transport |
| negative regulation of ion transmembrane transporter activity |
| modification by host of symbiont morphology or physiology |
| interaction with symbiont |
| regulation of cardiac muscle contraction |
| protein localization to mitochondrion |
| regulation of synaptic vesicle exocytosis |
| regulation of release of sequestered calcium ion into cytosol |
| negative regulation of transporter activity |
| negative regulation of cation transmembrane transport |
| voltage-gated potassium channel complex |
| midbrain development |
| regulation of calcium ion transmembrane transporter activity |
| regulation of cytokinesis |
| regulation of striated muscle contraction |
| regulation of oxidoreductase activity |
| negative regulation of ion transmembrane transport |
| regulation of calcium-mediated signaling |
| regulation of heart rate |
| regulation of calcium ion transport into cytosol |
| mitochondrial membrane |
| positive regulation of ion transmembrane transporter activity |
| regulation of neurotransmitter secretion |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| positive regulation of transporter activity |
| regulation of synaptic vesicle cycle |
| negative regulation of transmembrane transport |
| regulation of phosphoprotein phosphatase activity |
| positive regulation of calcium ion transport |
| spindle pole |
| regulation of sequestering of calcium ion |
| regulation of DNA binding |
| ion channel binding |
| mitochondrial membrane organization |
| growth cone |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| regulation of protein dephosphorylation |
| vesicle |
| positive regulation of cation transmembrane transport |
| regulation of neurotransmitter transport |
| response to glucocorticoid |
| calcium-mediated signaling |
| regulation of calcium ion transmembrane transport |
| negative regulation of ion transport |
| response to calcium ion |
| positive regulation of ion transmembrane transport |
| modification of morphology or physiology of other organism |
| regulation of muscle contraction |
| response to corticosteroid |
| regulation of regulated secretory pathway |
| regulation of cell division |
| regulation of cation channel activity |
| regulation of phosphatase activity |
| positive regulation of binding |
| response to ketone |
| positive regulation of transmembrane transport |
| regulation of endocytosis |
| regulation of dephosphorylation |
| regulation of exocytosis |
| response to alcohol |
| regulation of muscle system process |
| regulation of heart contraction |
| protein domain specific binding |
| regulation of calcium ion transport |
| regulation of ion transmembrane transporter activity |
| establishment of protein localization to membrane |
| regulation of transmembrane transporter activity |
| mitotic cell cycle phase transition |
| positive regulation of ion transport |
| regulation of transporter activity |
| cell cycle phase transition |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| response to xenobiotic stimulus |
| response to steroid hormone |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| positive regulation of protein serine/threonine kinase activity |
| regulation of neurotransmitter levels |
| response to metal ion |
| regulation of binding |
| regulation of metal ion transport |
| negative regulation of protein phosphorylation |
| establishment of protein localization to organelle |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| mitochondrion organization |
| regulation of trans-synaptic signaling |
| negative regulation of phosphorylation |
| calcium ion homeostasis |
| protein kinase binding |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| centrosome |
| response to toxic substance |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| detection of chemical stimulus |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| positive regulation of kinase activity |
| regulation of system process |
| negative regulation of protein modification process |
| protein-containing complex |
| mitotic cell cycle process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| mitotic cell cycle |
| detection of stimulus |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| protein localization to organelle |
| brain development |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of cell cycle process |
| positive regulation of hydrolase activity |
| head development |
| symbiotic process |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| interspecies interaction between organisms |
| response to lipid |
| membrane organization |
| regulation of kinase activity |
| cellular homeostasis |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of transferase activity |
| central nervous system development |
| positive regulation of transport |
| cell cycle process |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| G protein-coupled receptor signaling pathway |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4491
- Expression level (log2 read counts): 8.02
Expression Distribution
CALM3 Expression in NALM6 Cells: 8.02
