CAMK2B [The Human Chemical-Genetic Interaction Map Project]

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======= CAMK2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMK2B
  * **<color #00a2e8>Official Name</color>**: calcium/calmodulin dependent protein kinase II beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=816|816]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13554|Q13554]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMK2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMK2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607707|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|CaMKII AD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of synapse structural plasticity|
|positive regulation of synapse maturation|
|regulation of synapse maturation|
|regulation of skeletal muscle adaptation|
|positive regulation of dendritic spine morphogenesis|
|calmodulin-dependent protein kinase activity|
|regulation of long-term neuronal synaptic plasticity|
|sarcoplasmic reticulum membrane|
|positive regulation of dendrite morphogenesis|
|regulation of neuron migration|
|regulation of dendritic spine morphogenesis|
|positive regulation of dendritic spine development|
|regulation of neuronal synaptic plasticity|
|endocytic vesicle membrane|
|interferon-gamma-mediated signaling pathway|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|regulation of cellular response to heat|
|regulation of muscle adaptation|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|microtubule organizing center|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|regulation of synaptic plasticity|
|protein autophosphorylation|
|calmodulin binding|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|regulation of muscle system process|
|regulation of calcium ion transport|
|actin binding|
|synapse|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|neuron projection|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of system process|
|regulation of neuron differentiation|
|cytokine-mediated signaling pathway|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|regulation of cellular response to stress|
|innate immune response|
|regulation of neurogenesis|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|defense response to other organism|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to cytokine|
|positive regulation of cellular component organization|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.75|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.41|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.52|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.61|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.82|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.84|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.12|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.38|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5227
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMK2B Expression in NALM6 Cells: 1.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>