CAMK2B

Gene Information

Official Symbol: CAMK2B
Official Name: calcium/calmodulin dependent protein kinase II beta
Aliases and Previous Symbols: N/A
Entrez ID: 816
UniProt: Q13554
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 30μM R08 exp430	1.75
Nocodazole 0.2μM R02 exp64	2.41
Nocodazole 0.2μM R00 exp24	2.52
DABN racemic mixture R03 exp93	2.61
SB743921 0.001μM R05 exp244	2.82
Rotenone 2μM R00 exp33	2.84
R-DABN 8μM R03 exp111	3.12
Vinblastine 0.015μM R05 exp208	3.38
Nocodazole 0.1μM R03 exp94	3.61

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5227
Expression level (log2 read counts): 1.18

Expression Distribution

Pkinase
Pkinase Tyr
CaMKII AD

regulation of synapse structural plasticity
positive regulation of synapse maturation
regulation of synapse maturation
regulation of skeletal muscle adaptation
positive regulation of dendritic spine morphogenesis
calmodulin-dependent protein kinase activity
regulation of long-term neuronal synaptic plasticity
sarcoplasmic reticulum membrane
positive regulation of dendrite morphogenesis
regulation of neuron migration
regulation of dendritic spine morphogenesis
positive regulation of dendritic spine development
regulation of neuronal synaptic plasticity
endocytic vesicle membrane
interferon-gamma-mediated signaling pathway
regulation of dendritic spine development
positive regulation of dendrite development
regulation of cellular response to heat
regulation of muscle adaptation
regulation of dendrite morphogenesis
regulation of postsynapse organization
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
microtubule organizing center
cellular response to interferon-gamma
response to interferon-gamma
regulation of synaptic plasticity
protein autophosphorylation
calmodulin binding
regulation of synapse organization
regulation of synapse structure or activity
regulation of muscle system process
regulation of calcium ion transport
actin binding
synapse
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
neuron projection
positive regulation of neuron differentiation
positive regulation of cell projection organization