CAMSAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CAMSAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMSAP2
  * **<color #00a2e8>Official Name</color>**: calmodulin regulated spectrin associated protein family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23271|23271]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08AD1|Q08AD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMSAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMSAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAMSAP CKK|
|CAMSAP CH|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule end|
|microtubule minus-end|
|microtubule minus-end binding|
|regulation of Golgi organization|
|negative regulation of microtubule depolymerization|
|spectrin binding|
|regulation of microtubule depolymerization|
|negative regulation of microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|cytoplasmic microtubule organization|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|regulation of protein complex disassembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|regulation of dendrite development|
|regulation of microtubule cytoskeleton organization|
|calmodulin binding|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|axon development|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of neuron projection development|
|regulation of cytoskeleton organization|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|neuron development|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|generation of neurons|
|neurogenesis|
|cell development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.93|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.7|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMSAP2 Expression in NALM6 Cells: 4.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>