CAMSAP2

Gene Information

Official Symbol: CAMSAP2
Official Name: calmodulin regulated spectrin associated protein family member 2
Aliases and Previous Symbols: N/A
Entrez ID: 23271
UniProt: Q08AD1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18068
Expression level (log2 read counts): 4.76

Expression Distribution

Screen	Score
Celastrol 0.12μM R05 exp225	-1.93
Selumetinib 20μM R02 exp81	-1.7
DKK1 89ng/ml R08 exp477	1.76

CAMSAP CKK
CAMSAP CH
CH

microtubule end
microtubule minus-end
microtubule minus-end binding
regulation of Golgi organization
negative regulation of microtubule depolymerization
spectrin binding
regulation of microtubule depolymerization
negative regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
cytoplasmic microtubule organization
negative regulation of protein depolymerization
negative regulation of protein complex disassembly
regulation of microtubule polymerization or depolymerization
regulation of protein depolymerization
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
regulation of dendrite development
regulation of microtubule cytoskeleton organization
calmodulin binding
regulation of microtubule-based process
regulation of protein polymerization
regulation of supramolecular fiber organization
negative regulation of organelle organization
axon development
regulation of protein complex assembly
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
regulation of neuron projection development
regulation of cytoskeleton organization
regulation of neuron differentiation
neuron projection development
microtubule-based process
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
neuron development
regulation of neurogenesis
regulation of nervous system development