CANX [The Human Chemical-Genetic Interaction Map Project]

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======= CANX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CANX
  * **<color #00a2e8>Official Name</color>**: calnexin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=821|821]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27824|P27824]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CANX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CANX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114217|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calreticulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-35-mediated signaling pathway|
|interleukin-27-mediated signaling pathway|
|mitochondria-associated endoplasmic reticulum membrane|
|integral component of presynaptic active zone membrane|
|apolipoprotein binding|
|protein folding in endoplasmic reticulum|
|endoplasmic reticulum quality control compartment|
|clathrin-dependent endocytosis|
|smooth endoplasmic reticulum|
|integral component of lumenal side of endoplasmic reticulum membrane|
|dendrite cytoplasm|
|ionotropic glutamate receptor binding|
|ribosome|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|integral component of postsynaptic membrane|
|synaptic vesicle recycling|
|rough endoplasmic reticulum|
|antigen processing and presentation of peptide antigen via MHC class I|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|melanosome|
|endoplasmic reticulum unfolded protein response|
|synaptic vesicle cycle|
|cellular response to unfolded protein|
|vesicle-mediated transport in synapse|
|unfolded protein binding|
|cellular response to topologically incorrect protein|
|dendritic spine|
|protein secretion|
|establishment of protein localization to extracellular region|
|response to unfolded protein|
|protein localization to extracellular region|
|carbohydrate binding|
|peptide secretion|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|response to topologically incorrect protein|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|protein folding|
|receptor-mediated endocytosis|
|response to endoplasmic reticulum stress|
|aging|
|axon|
|endoplasmic reticulum lumen|
|glutamatergic synapse|
|neuronal cell body|
|endocytosis|
|cytokine-mediated signaling pathway|
|import into cell|
|calcium ion binding|
|endoplasmic reticulum membrane|
|secretion by cell|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|export from cell|
|response to cytokine|
|secretion|
|RNA binding|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.78|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.44|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.27|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.18|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.96|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.93|
|[[:results:exp539|42°C R08 exp539]]|-1.87|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.8|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.75|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.71|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.77|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.83|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.87|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.05|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8131
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CANX Expression in NALM6 Cells: 10.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>