CANX

Gene Information

Official Symbol: CANX
Official Name: calnexin
Aliases and Previous Symbols: N/A
Entrez ID: 821
UniProt: P27824
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-2.78
Rotenone 20μM R00 exp34	-2.44
Epothilone-B 0.0015μM R05 exp231	-2.27
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.18
VER-155008 3.9μM R06 exp301	-1.96
SNS-032 15μM R08 exp443	-1.93
42°C R08 exp539	-1.87
Etoposide 0.3μM R05 exp199	-1.8
Vemurafenib 6.6μM R08 exp434	-1.75
Cytochalasin-B 5μM R07 exp349	1.71
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.77
AICAR 240μM R03 exp116	1.83
YM155 0.001μM R08 exp432	1.87
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.05
Erlotinib 10μM R05 exp216	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8131
Expression level (log2 read counts): 10.26

Expression Distribution

interleukin-35-mediated signaling pathway
interleukin-27-mediated signaling pathway
mitochondria-associated endoplasmic reticulum membrane
integral component of presynaptic active zone membrane
apolipoprotein binding
protein folding in endoplasmic reticulum
endoplasmic reticulum quality control compartment
clathrin-dependent endocytosis
smooth endoplasmic reticulum
integral component of lumenal side of endoplasmic reticulum membrane
dendrite cytoplasm
ionotropic glutamate receptor binding
ribosome
synaptic vesicle endocytosis
presynaptic endocytosis
integral component of postsynaptic membrane
synaptic vesicle recycling
rough endoplasmic reticulum
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
melanosome
endoplasmic reticulum unfolded protein response
synaptic vesicle cycle
cellular response to unfolded protein
vesicle-mediated transport in synapse
unfolded protein binding
cellular response to topologically incorrect protein
dendritic spine
protein secretion
establishment of protein localization to extracellular region
response to unfolded protein
protein localization to extracellular region
carbohydrate binding
peptide secretion
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
response to topologically incorrect protein
antigen processing and presentation of peptide antigen