CAP1

Entrez Summary: N/A
UniProt Summary: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 86/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	3/28
bone	0/26
breast	7/33
central nervous system	1/56
cervix	2/4
colorectal	6/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	2/20
lung	10/75
lymphocyte	3/16
ovary	2/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	10/22
urinary tract	6/29
uterus	0/5

Expression Distribution

CAP N
CAP C

adenylate cyclase binding
activation of adenylate cyclase activity
actin polymerization or depolymerization
cortical actin cytoskeleton
azurophil granule lumen
ameboidal-type cell migration
establishment or maintenance of cell polarity
receptor-mediated endocytosis
actin filament organization
actin binding
focal adhesion
supramolecular fiber organization
neutrophil degranulation
neutrophil activation involved in immune response
actin cytoskeleton organization
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
endocytosis
actin filament-based process
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
import into cell
regulated exocytosis
cell morphogenesis
leukocyte mediated immunity
exocytosis
cellular component morphogenesis
leukocyte activation
cell migration
secretion by cell
export from cell
cell activation
cell motility
localization of cell
immune effector process