CAPG

Entrez Summary: N/A
UniProt Summary: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

F-actin capping protein complex
positive regulation of podosome assembly
barbed-end actin filament capping
regulation of podosome assembly
Flemming body
actin filament capping
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
extracellular matrix disassembly
negative regulation of protein polymerization
negative regulation of protein complex disassembly
positive regulation of organelle assembly
mitotic spindle
regulation of protein depolymerization
ruffle
melanosome
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
negative regulation of cytoskeleton organization
centriole
regulation of actin filament polymerization
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length
actin filament binding
regulation of organelle assembly
regulation of protein polymerization
protein domain specific binding
positive regulation of protein complex assembly
regulation of actin filament organization
protein-containing complex binding
cadherin binding
extracellular matrix organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
negative regulation of organelle organization
regulation of cellular component size