CAPN3
Gene Information
- Official Symbol: CAPN3
- Official Name: calpain 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 825
- UniProt: P20807
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008].
- UniProt Summary: Calcium-regulated non-lysosomal thiol-protease.
Pfam Domains GO Terms
Pfam Domains
| Peptidase C2 |
| efhand |
| Calpain III |
GO Terms
| ligase regulator activity |
| calcium-dependent self proteolysis |
| positive regulation of satellite cell activation involved in skeletal muscle regeneration |
| regulation of satellite cell activation involved in skeletal muscle regeneration |
| G1 to G0 transition involved in cell differentiation |
| positive regulation of skeletal muscle tissue regeneration |
| self proteolysis |
| sodium ion binding |
| cellular response to salt stress |
| regulation of skeletal muscle tissue regeneration |
| G1 to G0 transition |
| negative regulation of protein sumoylation |
| titin binding |
| calcium-dependent cysteine-type endopeptidase activity |
| muscle cell cellular homeostasis |
| regulation of protein sumoylation |
| response to salt stress |
| response to muscle activity |
| myofibril |
| cysteine-type peptidase activity |
| cellular response to osmotic stress |
| positive regulation of release of sequestered calcium ion into cytosol |
| T-tubule |
| catalytic activity |
| structural constituent of muscle |
| protein destabilization |
| sarcomere organization |
| molecular adaptor activity |
| regulation of myoblast differentiation |
| positive regulation of calcium ion transport into cytosol |
| positive regulation of wound healing |
| positive regulation of response to wounding |
| response to activity |
| myofibril assembly |
| positive regulation of calcium ion transmembrane transport |
| response to osmotic stress |
| regulation of release of sequestered calcium ion into cytosol |
| peptidase activity |
| negative regulation of protein modification by small protein conjugation or removal |
| cellular response to calcium ion |
| intracellular |
| regulation of calcium ion transport into cytosol |
| cellular component assembly involved in morphogenesis |
| actomyosin structure organization |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| Z disc |
| striated muscle cell development |
| regulation of wound healing |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| muscle cell development |
| response to calcium ion |
| positive regulation of NF-kappaB transcription factor activity |
| positive regulation of ion transmembrane transport |
| regulation of response to wounding |
| positive regulation of developmental growth |
| cellular response to metal ion |
| striated muscle cell differentiation |
| positive regulation of transmembrane transport |
| cellular response to inorganic substance |
| regulation of protein modification by small protein conjugation or removal |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| muscle cell differentiation |
| regulation of calcium ion transport |
| positive regulation of growth |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of protein stability |
| muscle organ development |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| regulation of cytosolic calcium ion concentration |
| regulation of developmental growth |
| regulation of cation transmembrane transport |
| anatomical structure homeostasis |
| positive regulation of proteolysis |
| response to metal ion |
| regulation of metal ion transport |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| supramolecular fiber organization |
| cellular divalent inorganic cation homeostasis |
| muscle structure development |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| divalent inorganic cation homeostasis |
| actin cytoskeleton organization |
| response to inorganic substance |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| actin filament-based process |
| negative regulation of protein modification process |
| protein-containing complex |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| regulation of growth |
| protein catabolic process |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of proteolysis |
| cellular chemical homeostasis |
| organelle assembly |
| ion homeostasis |
| cellular component morphogenesis |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| apoptotic process |
| positive regulation of transport |
| negative regulation of cell death |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| cell death |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| chemical homeostasis |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| proteolysis |
| negative regulation of RNA metabolic process |
| cell cycle |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCCP 0.1μM R00 exp10 | 1.71 |
| Docosahexaenoic-acid 50μM R07 exp356 | 1.77 |
| I-BRD9 4μM R07 exp365 | 1.82 |
| Cannabidiol 13μM R08 exp465 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5111
- Expression level (log2 read counts): 3.33
Expression Distribution
CAPN3 Expression in NALM6 Cells: 3.33
