CAPNS1

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium-dependent cysteine-type endopeptidase activity
extracellular matrix disassembly
cornification
regulation of macroautophagy
keratinization
keratinocyte differentiation
epidermal cell differentiation
regulation of autophagy
extracellular matrix organization
skin development
extracellular structure organization
cellular component disassembly
epidermis development
epithelial cell differentiation
calcium ion binding
regulation of cellular catabolic process
positive regulation of cell population proliferation
regulation of catabolic process
programmed cell death
cell death
epithelium development
proteolysis
regulation of cell population proliferation
tissue development
membrane