CAPZA1

Gene Information

Official Symbol: CAPZA1
Official Name: capping actin protein of muscle Z-line subunit alpha 1
Aliases and Previous Symbols: N/A
Entrez ID: 829
UniProt: P52907
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. {ECO:0000269|PubMed:22891260}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-3.03
Clomiphene 4.4μM R02 exp68	-2.07
Rapamycin 2μM R07 exp306	-2
Deguelin 0.15μM R05 exp209	-1.99
MLN-4924 0.2μM R00 exp21	-1.93
MK-1775 0.32μM R02 exp75	1.7
Mdivi-1 15μM R05 exp217	2.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8201
Expression level (log2 read counts): 7.54

Expression Distribution

F-actin capping protein complex
barbed-end actin filament capping
WASH complex
actin cortical patch
actin filament capping
negative regulation of actin filament depolymerization
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
negative regulation of protein polymerization
negative regulation of protein complex disassembly
regulation of protein depolymerization
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
negative regulation of cytoskeleton organization
regulation of actin filament polymerization
cell junction assembly
antigen processing and presentation of exogenous peptide antigen
regulation of actin polymerization or depolymerization
regulation of actin filament length
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
actin filament binding
endoplasmic reticulum to Golgi vesicle-mediated transport
cell junction organization
antigen processing and presentation
actin cytoskeleton
regulation of protein polymerization
regulation of actin filament organization
actin binding
blood coagulation
coagulation
hemostasis