CARD17

Entrez Summary: N/A
UniProt Summary: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. {ECO:0000269|PubMed:15383541}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	-2.1
YM155 0.0002μM R01 exp61	1.78
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.98

caspase binding
negative regulation of interleukin-1 beta secretion
negative regulation of interleukin-1 secretion
negative regulation of interleukin-1 beta production
negative regulation of interleukin-1 production
cysteine-type endopeptidase inhibitor activity
regulation of interleukin-1 beta secretion
regulation of interleukin-1 secretion
negative regulation of cytokine secretion
regulation of interleukin-1 beta production
regulation of interleukin-1 production
negative regulation of protein secretion
negative regulation of peptide secretion
negative regulation of protein transport
cellular response to lipopolysaccharide
negative regulation of establishment of protein localization
cellular response to molecule of bacterial origin
negative regulation of secretion by cell
regulation of cytokine secretion
cellular response to biotic stimulus
negative regulation of secretion
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of cytokine production
response to lipopolysaccharide
response to molecule of bacterial origin
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
cellular response to lipid
protein-containing complex
response to bacterium
regulation of cytokine production
regulation of protein transport
regulation of proteolysis
regulation of peptide transport