CASP3 [The Human Chemical-Genetic Interaction Map Project]

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======= CASP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CASP3
  * **<color #00a2e8>Official Name</color>**: caspase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=836|836]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42574|P42574]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CASP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CASP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600636|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intrinsic apoptotic signaling pathway in response to osmotic stress|
|phospholipase A2 activator activity|
|anterior neural tube closure|
|cysteine-type endopeptidase activity involved in execution phase of apoptosis|
|cellular response to staurosporine|
|response to staurosporine|
|glial cell apoptotic process|
|death-inducing signaling complex|
|luteolysis|
|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|response to cobalt ion|
|negative regulation of activated T cell proliferation|
|cyclin-dependent protein serine/threonine kinase inhibitor activity|
|positive regulation of amyloid-beta formation|
|death receptor binding|
|cysteine-type endopeptidase activity involved in apoptotic process|
|apoptotic DNA fragmentation|
|negative regulation of B cell proliferation|
|platelet formation|
|positive regulation of amyloid precursor protein catabolic process|
|platelet morphogenesis|
|neurotrophin TRK receptor signaling pathway|
|aspartic-type endopeptidase activity|
|axonal fasciculation|
|neuron projection fasciculation|
|DNA catabolic process, endonucleolytic|
|leukocyte apoptotic process|
|B cell homeostasis|
|apoptotic nuclear changes|
|hippo signaling|
|cellular component disassembly involved in execution phase of apoptosis|
|regulation of amyloid-beta formation|
|neurotrophin signaling pathway|
|response to X-ray|
|DNA catabolic process|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|negative regulation of B cell activation|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|T cell homeostasis|
|regulation of amyloid precursor protein catabolic process|
|cellular response to alkaloid|
|cellular response to osmotic stress|
|regulation of activated T cell proliferation|
|ovulation cycle process|
|neuron apoptotic process|
|neuron recognition|
|response to nicotine|
|neuron death|
|execution phase of apoptosis|
|lymphocyte homeostasis|
|positive regulation of neuron apoptotic process|
|negative regulation of T cell proliferation|
|regulation of B cell proliferation|
|ovulation cycle|
|leukocyte homeostasis|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|response to osmotic stress|
|negative regulation of leukocyte proliferation|
|erythrocyte differentiation|
|hippocampus development|
|peptidase activity|
|female gonad development|
|erythrocyte homeostasis|
|neural tube closure|
|tube closure|
|positive regulation of neuron death|
|cysteine-type endopeptidase activity|
|development of primary female sexual characteristics|
|extrinsic apoptotic signaling pathway|
|primary neural tube formation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|protease binding|
|regulation of cyclin-dependent protein kinase activity|
|neural tube formation|
|female sex differentiation|
|myeloid cell homeostasis|
|limbic system development|
|negative regulation of T cell activation|
|response to alkaloid|
|response to amino acid|
|response to hydrogen peroxide|
|negative regulation of leukocyte cell-cell adhesion|
|embryonic epithelial tube formation|
|cellular response to ammonium ion|
|epithelial tube formation|
|negative regulation of protein serine/threonine kinase activity|
|response to estradiol|
|response to glucose|
|response to UV|
|response to hexose|
|morphogenesis of embryonic epithelium|
|negative regulation of lymphocyte activation|
|response to glucocorticoid|
|sensory perception of sound|
|tube formation|
|response to ionizing radiation|
|intrinsic apoptotic signaling pathway|
|response to monosaccharide|
|positive regulation of cellular amide metabolic process|
|regulation of T cell proliferation|
|protein processing|
|neural tube development|
|response to corticosteroid|
|sensory perception of mechanical stimulus|
|response to carbohydrate|
|regulation of macroautophagy|
|pallium development|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|response to ammonium ion|
|response to reactive oxygen species|
|negative regulation of cell activation|
|homeostasis of number of cells|
|striated muscle cell differentiation|
|regulation of neuron apoptotic process|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|gonad development|
|regulation of mononuclear cell proliferation|
|development of primary sexual characteristics|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|protein maturation|
|membrane raft|
|negative regulation of protein kinase activity|
|cell recognition|
|muscle cell differentiation|
|cell fate commitment|
|negative regulation of kinase activity|
|telencephalon development|
|learning or memory|
|response to tumor necrosis factor|
|sex differentiation|
|protein-containing complex binding|
|negative regulation of cell adhesion|
|keratinocyte differentiation|
|rhythmic process|
|negative regulation of transferase activity|
|apoptotic signaling pathway|
|regulation of protein stability|
|regulation of leukocyte cell-cell adhesion|
|nucleic acid phosphodiester bond hydrolysis|
|cognition|
|response to antibiotic|
|response to light stimulus|
|epithelial tube morphogenesis|
|regulation of neuron death|
|response to lipopolysaccharide|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|epidermal cell differentiation|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of autophagy|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|response to metal ion|
|neuronal cell body|
|nucleobase-containing compound catabolic process|
|response to oxygen levels|
|skin development|
|forebrain development|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|axon development|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|response to radiation|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|negative regulation of phosphorylation|
|muscle structure development|
|wound healing|
|organic cyclic compound catabolic process|
|cellular response to growth factor stimulus|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|heart development|
|response to growth factor|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|behavior|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cell adhesion|
|response to bacterium|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|sensory perception|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.7|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.73|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.85|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.9|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|8.14|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|8.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fadd|FADD]]|0.652|
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.625|
|[[:human genes:c:casp8|CASP8]]|0.615|
|[[:human genes:c:ccnc|CCNC]]|0.56|
|[[:human genes:m:mtmr4|MTMR4]]|0.559|
|[[:human genes:f:fnip1|FNIP1]]|0.519|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.511|
|[[:human genes:c:cxorf38|CXorf38]]|0.506|
|[[:human genes:f:flcn|FLCN]]|0.497|
|[[:human genes:f:fbxo11|FBXO11]]|0.483|
|[[:human genes:u:ube3a|UBE3A]]|0.473|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.47|
|[[:human genes:f:fbxl17|FBXL17]]|0.469|
|[[:human genes:c:cdk6|CDK6]]|0.455|
|[[:human genes:b:btaf1|BTAF1]]|0.449|
|[[:human genes:e:elavl1|ELAVL1]]|0.436|
|[[:human genes:h:hnrnpl|HNRNPL]]|0.435|
|[[:human genes:c:chd7|CHD7]]|0.424|
|[[:human genes:c:creb1|CREB1]]|0.407|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.405|
|[[:human genes:w:wdr24|WDR24]]|0.402|
|[[:human genes:t:trim25|TRIM25]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CASP3 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>