CASP3

Gene Information

Official Symbol: CASP3
Official Name: caspase 3
Aliases and Previous Symbols: N/A
Entrez ID: 836
UniProt: P42574
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	1.7
Trametinib 10μM R02 exp83	1.73
Staurosporine 0.02μM R08 exp524	1.85
MS023 7μM R03 exp135	1.9
TRAIL 5ng/ml R00 exp35	8.14
TRAIL 50ng/ml R00 exp36	8.5

Gene	Correlation
FADD	0.652
TNFRSF10B	0.625
CASP8	0.615
CCNC	0.56
MTMR4	0.559
FNIP1	0.519
KHDRBS1	0.511
CXorf38	0.506
FLCN	0.497
FBXO11	0.483
UBE3A	0.473
LAMTOR2	0.47
FBXL17	0.469
CDK6	0.455
BTAF1	0.449
ELAVL1	0.436
HNRNPL	0.435
CHD7	0.424
CREB1	0.407
LAMTOR4	0.405
WDR24	0.402
TRIM25	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17662
Expression level (log2 read counts): 5.65

Expression Distribution

intrinsic apoptotic signaling pathway in response to osmotic stress
phospholipase A2 activator activity
anterior neural tube closure
cysteine-type endopeptidase activity involved in execution phase of apoptosis
cellular response to staurosporine
response to staurosporine
glial cell apoptotic process
death-inducing signaling complex
luteolysis
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
response to cobalt ion
negative regulation of activated T cell proliferation
cyclin-dependent protein serine/threonine kinase inhibitor activity
positive regulation of amyloid-beta formation
death receptor binding
cysteine-type endopeptidase activity involved in apoptotic process
apoptotic DNA fragmentation
negative regulation of B cell proliferation
platelet formation
positive regulation of amyloid precursor protein catabolic process
platelet morphogenesis
neurotrophin TRK receptor signaling pathway
aspartic-type endopeptidase activity
axonal fasciculation
neuron projection fasciculation
DNA catabolic process, endonucleolytic
leukocyte apoptotic process
B cell homeostasis
apoptotic nuclear changes
hippo signaling
cellular component disassembly involved in execution phase of apoptosis
regulation of amyloid-beta formation
neurotrophin signaling pathway
response to X-ray
DNA catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cyclin-dependent protein kinase activity
negative regulation of B cell activation
extrinsic apoptotic signaling pathway in absence of ligand
signal transduction in absence of ligand