TNFRSF10B

Gene Information

Official Symbol: TNFRSF10B
Official Name: TNF receptor superfamily member 10b
Aliases and Previous Symbols: N/A
Entrez ID: 8795
UniProt: O14763
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009].
UniProt Summary: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:10542098, ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:15322075}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
FADD	0.682
CASP8	0.644
CASP3	0.625
CXorf38	0.598
CCNC	0.442
ELAVL1	0.435
FNIP1	0.434
IKZF2	0.432
ZNF217	0.426
TRIM25	0.426
MTMR4	0.421
FLCN	0.415
ZC3HAV1	0.414
CHD7	0.413
SAFB	0.407
KHDRBS1	0.406

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3770
Expression level (log2 read counts): 6.59

Expression Distribution

Screen	Score
Radicicol 0.16μM R05 exp242	1.75
TRAIL 50ng/ml R00 exp36	7.62
TRAIL 5ng/ml R00 exp35	7.74

TNFR c6
Death

TRAIL-activated apoptotic signaling pathway
TRAIL binding
activation of NF-kappaB-inducing kinase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of NIK/NF-kappaB signaling
cellular response to mechanical stimulus
NIK/NF-kappaB signaling
activation of cysteine-type endopeptidase activity involved in apoptotic process
extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
regulation of NIK/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
intrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity
regulation of extrinsic apoptotic signaling pathway
positive regulation of endopeptidase activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of peptidase activity
signaling receptor activity
response to mechanical stimulus
regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of apoptotic signaling pathway
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cysteine-type endopeptidase activity
response to endoplasmic reticulum stress
apoptotic signaling pathway
cellular response to abiotic stimulus
cellular response to environmental stimulus
activation of protein kinase activity
cellular response to external stimulus
positive regulation of proteolysis
leukocyte migration
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of protein kinase activity
positive regulation of kinase activity