MTMR4
Gene Information
- Official Symbol: MTMR4
- Official Name: myotubularin related protein 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 9110
- UniProt: Q9NYA4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). {ECO:0000269|PubMed:11302699}.
Pfam Domains GO Terms
Pfam Domains
| FYVE |
| Myotub-related |
GO Terms
| regulation of phosphatidylinositol dephosphorylation |
| response to muscle inactivity involved in regulation of muscle adaptation |
| response to denervation involved in regulation of muscle adaptation |
| response to muscle inactivity |
| response to inactivity |
| response to stimulus involved in regulation of muscle adaptation |
| protein serine/threonine phosphatase activity |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| regulation of phospholipid metabolic process |
| regulation of muscle adaptation |
| protein phosphatase binding |
| protein tyrosine phosphatase activity |
| transforming growth factor beta receptor signaling pathway |
| peptidyl-tyrosine dephosphorylation |
| phosphatidylinositol biosynthetic process |
| regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| negative regulation of cellular response to growth factor stimulus |
| early endosome membrane |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| phosphatidylinositol metabolic process |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| glycerophospholipid biosynthetic process |
| regulation of dephosphorylation |
| protein dephosphorylation |
| glycerolipid biosynthetic process |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of muscle system process |
| phospholipid biosynthetic process |
| endosome |
| regulation of cellular response to growth factor stimulus |
| glycerophospholipid metabolic process |
| dephosphorylation |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| regulation of lipid metabolic process |
| cellular response to growth factor stimulus |
| response to growth factor |
| organophosphate biosynthetic process |
| lipid biosynthetic process |
| regulation of system process |
| enzyme linked receptor protein signaling pathway |
| organophosphate metabolic process |
| cellular lipid metabolic process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| response to endogenous stimulus |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8461
- Expression level (log2 read counts): 7.54
Expression Distribution
MTMR4 Expression in NALM6 Cells: 7.54
