CATSPERD

Entrez Summary: N/A
UniProt Summary: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane. {ECO:0000250|UniProtKB:E9Q9F6}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CatSper complex
sperm principal piece
sperm capacitation
response to progesterone
sperm-egg recognition
cell-cell recognition
flagellated sperm motility
sperm motility
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
single fertilization
spermatid development
spermatid differentiation
cell maturation
fertilization
response to ketone
cell recognition
developmental maturation
germ cell development
response to steroid hormone
cellular process involved in reproduction in multicellular organism
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
response to lipid
response to hormone
response to organic cyclic compound
multi-organism reproductive process
response to drug
cell motility
localization of cell
locomotion
reproductive process
reproduction
response to endogenous stimulus
movement of cell or subcellular component