CBFA2T2

Gene Information

Official Symbol: CBFA2T2
Official Name: CBFA2/RUNX1 partner transcriptional co-repressor 2
Aliases and Previous Symbols: N/A
Entrez ID: 9139
UniProt: O43439
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10929
Expression level (log2 read counts): 5.46

Expression Distribution

zf-MYND
TAFH
NHR2

intestinal epithelial cell differentiation
negative regulation of Notch signaling pathway
columnar/cuboidal epithelial cell differentiation
regulation of Notch signaling pathway
digestive tract development
digestive system development
negative regulation of neuron projection development
negative regulation of cell projection organization
negative regulation of neuron differentiation
transcription corepressor activity
positive regulation of neuron projection development
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
positive regulation of neuron differentiation
positive regulation of cell projection organization
positive regulation of neurogenesis
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
DNA-binding transcription factor activity
epithelial cell differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
regulation of neurogenesis
tube development
negative regulation of transcription by RNA polymerase II
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
positive regulation of cell differentiation
epithelium development
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
positive regulation of cellular component organization
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process