CBR1 [The Human Chemical-Genetic Interaction Map Project]

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======= CBR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CBR1
  * **<color #00a2e8>Official Name</color>**: carbonyl reductase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=873|873]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16152|P16152]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CBR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CBR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. {ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
|KR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|15-hydroxyprostaglandin dehydrogenase (NADP+) activity|
|prostaglandin-E2 9-reductase activity|
|carbonyl reductase (NADPH) activity|
|vitamin K metabolic process|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|
|cyclooxygenase pathway|
|prostaglandin biosynthetic process|
|prostanoid biosynthetic process|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|fat-soluble vitamin metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|extracellular vesicle|
|arachidonic acid metabolic process|
|fatty acid derivative biosynthetic process|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|vitamin metabolic process|
|fatty acid derivative metabolic process|
|monocarboxylic acid biosynthetic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|epithelial cell differentiation|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|epithelium development|
|lipid metabolic process|
|small molecule metabolic process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13937
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CBR1 Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>