CBR1

Entrez Summary: N/A
UniProt Summary: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. {ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adh short
KR

15-hydroxyprostaglandin dehydrogenase (NADP+) activity
prostaglandin-E2 9-reductase activity
carbonyl reductase (NADPH) activity
vitamin K metabolic process
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
cyclooxygenase pathway
prostaglandin biosynthetic process
prostanoid biosynthetic process
prostaglandin metabolic process
prostanoid metabolic process
fat-soluble vitamin metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
extracellular vesicle
arachidonic acid metabolic process
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
vitamin metabolic process
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
drug metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
epithelial cell differentiation
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
epithelium development
lipid metabolic process
small molecule metabolic process
tissue development