CCBL1

Entrez Summary: N/A
UniProt Summary: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. {ECO:0000269|PubMed:19338303}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glutamine-phenylpyruvate transaminase activity
cysteine-S-conjugate beta-lyase activity
L-kynurenine catabolic process
kynurenine-oxoglutarate transaminase activity
transaminase activity
L-kynurenine metabolic process
ketone catabolic process
tryptophan catabolic process
indole-containing compound catabolic process
indolalkylamine catabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
L-phenylalanine catabolic process
kynurenine metabolic process
L-phenylalanine metabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
tryptophan metabolic process
indolalkylamine metabolic process
cellular biogenic amine catabolic process
amine catabolic process
indole-containing compound metabolic process
benzene-containing compound metabolic process
aromatic amino acid family catabolic process
aromatic amino acid family metabolic process
pyridoxal phosphate binding
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
cellular ketone metabolic process
cellular amino acid biosynthetic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
drug catabolic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
heterocycle catabolic process