CCDC11 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CFAP53
  * **<color #00a2e8>Official Name</color>**: cilia and flagella associated protein 53
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=220136|220136]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96M91|Q96M91]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614759|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the CFAP53 family. It was found to be differentially expressed by the ciliated cells of frog epidermis and in skin fibroblasts from human. Mutations in this gene are associated with visceral heterotaxy-6, which implicates this gene in determination of left-right asymmetric patterning. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. {ECO:0000269|PubMed:26531781}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial cilium movement involved in determination of left/right asymmetry|
|epithelial cilium movement involved in extracellular fluid movement|
|extracellular transport|
|cilium movement|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|microtubule-based transport|
|cilium|
|microtubule-based movement|
|cilium assembly|
|cilium organization|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cellular component|
|cell projection assembly|
|microtubule-based process|
|organelle assembly|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|movement of cell or subcellular component|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.05|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.7|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.7|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.73|
|[[:results:exp302|35°C R06 exp302]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC11 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>