CCDC11

Entrez Summary: This gene belongs to the CFAP53 family. It was found to be differentially expressed by the ciliated cells of frog epidermis and in skin fibroblasts from human. Mutations in this gene are associated with visceral heterotaxy-6, which implicates this gene in determination of left-right asymmetric patterning. [provided by RefSeq, Aug 2015].
UniProt Summary: May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. {ECO:0000269|PubMed:26531781}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

epithelial cilium movement involved in determination of left/right asymmetry
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
cilium movement
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
microtubule-based transport
cilium
microtubule-based movement
cilium assembly
cilium organization
pattern specification process
plasma membrane bounded cell projection assembly
cellular component
cell projection assembly
microtubule-based process
organelle assembly
plasma membrane bounded cell projection organization
cell projection organization
movement of cell or subcellular component
extracellular region