CCDC36

Entrez Summary: N/A
UniProt Summary: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. {ECO:0000250|UniProtKB:Q6PDM4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of homologous chromosome segregation
meiotic DNA double-strand break formation
regulation of meiosis I
condensed nuclear chromosome
regulation of meiotic nuclear division
synapsis
regulation of meiotic cell cycle
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
oogenesis
meiotic chromosome segregation
regulation of chromosome segregation
meiosis I
meiosis I cell cycle process
female gamete generation
meiotic nuclear division
regulation of reproductive process
meiotic cell cycle process
regulation of nuclear division
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
germ cell development
chromosome segregation
nuclear division
nucleic acid phosphodiester bond hydrolysis
organelle fission
cellular process involved in reproduction in multicellular organism
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
DNA metabolic process
regulation of cell cycle process
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell cycle process
chromosome organization