CCDC86 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC86 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC86
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 86
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79080|79080]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6F5|Q9H6F5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC86&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC86|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611293|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.83|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.88|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.88|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.94|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.427|
|[[:human genes:c:cbwd5|CBWD5]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 282/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|9/28|
|bone|9/26|
|breast|9/33|
|central nervous system|19/56|
|cervix|2/4|
|colorectal|9/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|11/21|
|liver|9/20|
|lung|29/75|
|lymphocyte|5/16|
|ovary|11/26|
|pancreas|6/24|
|peripheral nervous system|7/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1584
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC86 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>