CCDC88C

Entrez Summary: This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013].
UniProt Summary: Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway (PubMed:25062847). {ECO:0000250|UniProtKB:Q6VGS5, ECO:0000269|PubMed:25062847}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dynein light intermediate chain binding
protein destabilization
cytoplasmic microtubule organization
protein self-association
PDZ domain binding
stress-activated protein kinase signaling cascade
cytoskeleton-dependent intracellular transport
microtubule binding
regulation of protein stability
protein homooligomerization
cell-cell signaling by wnt
Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
protein complex oligomerization
microtubule-based process
cytoskeleton organization
cell-cell signaling
regulation of protein phosphorylation
intracellular transport
protein-containing complex assembly
regulation of phosphorylation
intracellular signal transduction
cellular response to stress
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
establishment of localization in cell
regulation of protein modification process
protein-containing complex subunit organization