CCL11 [The Human Chemical-Genetic Interaction Map Project]

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======= CCL11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL11
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6356|6356]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51671|P51671]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601156|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mammary duct terminal end bud growth|
|CCR3 chemokine receptor binding|
|mast cell chemotaxis|
|mast cell migration|
|response to interleukin-13|
|modulation of age-related behavioral decline|
|chronic inflammatory response|
|eosinophil chemotaxis|
|eosinophil migration|
|branching involved in mammary gland duct morphogenesis|
|ERK1 and ERK2 cascade|
|CCR chemokine receptor binding|
|response to interleukin-4|
|mammary gland duct morphogenesis|
|receptor ligand activity|
|monocyte chemotaxis|
|mammary gland morphogenesis|
|lymphocyte chemotaxis|
|mononuclear cell migration|
|chemokine activity|
|mammary gland epithelium development|
|lymphocyte migration|
|chemokine-mediated signaling pathway|
|cell|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|neutrophil migration|
|positive regulation of actin filament polymerization|
|positive regulation of endothelial cell proliferation|
|gland morphogenesis|
|granulocyte migration|
|developmental growth involved in morphogenesis|
|mammary gland development|
|myeloid leukocyte migration|
|positive regulation of protein polymerization|
|regulation of endothelial cell proliferation|
|branching morphogenesis of an epithelial tube|
|leukocyte chemotaxis|
|regulation of cell shape|
|protein dimerization activity|
|morphogenesis of a branching epithelium|
|cellular response to interferon-gamma|
|positive regulation of angiogenesis|
|regulation of actin filament polymerization|
|morphogenesis of a branching structure|
|cellular response to interleukin-1|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|positive regulation of supramolecular fiber organization|
|response to interleukin-1|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|cellular response to tumor necrosis factor|
|actin filament organization|
|positive regulation of protein complex assembly|
|learning or memory|
|regulation of actin filament organization|
|response to tumor necrosis factor|
|aging|
|response to virus|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|cognition|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|regulation of vasculature development|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|MAPK cascade|
|regulation of cellular component size|
|leukocyte migration|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|gland development|
|positive regulation of GTPase activity|
|morphogenesis of an epithelium|
|cellular calcium ion homeostasis|
|response to radiation|
|calcium ion homeostasis|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|inflammatory response|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|actin filament-based process|
|behavior|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|innate immune response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to cytokine|
|cytoskeleton organization|
|chemical homeostasis|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17169
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL11 Expression in NALM6 Cells: -3.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>