CCL21
Gene Information
- Official Symbol: CCL21
- Official Name: C-C motif chemokine ligand 21
- Aliases and Previous Symbols: N/A
- Entrez ID: 6366
- UniProt: O00585
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| regulation of myeloid dendritic cell chemotaxis |
| negative regulation of dendritic cell dendrite assembly |
| positive regulation of myeloid dendritic cell chemotaxis |
| CCR7 chemokine receptor binding |
| dendritic cell dendrite assembly |
| mesangial cell-matrix adhesion |
| regulation of dendritic cell dendrite assembly |
| negative regulation of leukocyte tethering or rolling |
| chemokine (C-C motif) ligand 21 signaling pathway |
| negative regulation of leukocyte adhesion to vascular endothelial cell |
| establishment of T cell polarity |
| positive regulation of dendritic cell antigen processing and presentation |
| establishment of lymphocyte polarity |
| negative regulation of dendritic cell apoptotic process |
| chemokine receptor binding |
| positive regulation of dendritic cell chemotaxis |
| regulation of leukocyte tethering or rolling |
| negative regulation of cellular extravasation |
| positive regulation of antigen processing and presentation |
| regulation of dendritic cell chemotaxis |
| regulation of dendritic cell apoptotic process |
| regulation of dendritic cell antigen processing and presentation |
| positive regulation of pseudopodium assembly |
| immunological synapse formation |
| regulation of pseudopodium assembly |
| positive regulation of T cell chemotaxis |
| regulation of T cell chemotaxis |
| dendritic cell chemotaxis |
| regulation of leukocyte adhesion to vascular endothelial cell |
| positive regulation of glycoprotein biosynthetic process |
| positive regulation of cell adhesion mediated by integrin |
| regulation of antigen processing and presentation |
| dendritic cell migration |
| positive regulation of lymphocyte chemotaxis |
| positive regulation of glycoprotein metabolic process |
| response to prostaglandin E |
| positive regulation of neutrophil chemotaxis |
| ruffle organization |
| negative regulation of plasma membrane bounded cell projection assembly |
| regulation of lymphocyte chemotaxis |
| positive regulation of granulocyte chemotaxis |
| CCR chemokine receptor binding |
| regulation of cellular extravasation |
| positive regulation of neutrophil migration |
| regulation of neutrophil chemotaxis |
| positive regulation of filopodium assembly |
| response to prostaglandin |
| positive regulation of T cell migration |
| positive regulation of phosphatidylinositol 3-kinase activity |
| positive regulation of lipid kinase activity |
| regulation of neutrophil migration |
| positive regulation of lymphocyte migration |
| regulation of glycoprotein biosynthetic process |
| monocyte chemotaxis |
| regulation of granulocyte chemotaxis |
| regulation of T cell migration |
| negative regulation of leukocyte migration |
| regulation of filopodium assembly |
| regulation of glycoprotein metabolic process |
| negative regulation of leukocyte apoptotic process |
| regulation of cell adhesion mediated by integrin |
| lymphocyte chemotaxis |
| positive regulation of phospholipid metabolic process |
| mononuclear cell migration |
| chemokine activity |
| positive regulation of cell-matrix adhesion |
| positive regulation of receptor-mediated endocytosis |
| regulation of phosphatidylinositol 3-kinase activity |
| T cell costimulation |
| release of sequestered calcium ion into cytosol |
| lymphocyte costimulation |
| negative regulation of sequestering of calcium ion |
| regulation of lipid kinase activity |
| regulation of lymphocyte migration |
| lymphocyte migration |
| calcium ion transmembrane import into cytosol |
| cell-cell recognition |
| calcium ion transport into cytosol |
| chemokine-mediated signaling pathway |
| cell |
| regulation of leukocyte apoptotic process |
| neutrophil chemotaxis |
| regulation of phospholipid metabolic process |
| response to fatty acid |
| positive regulation of leukocyte chemotaxis |
| granulocyte chemotaxis |
| cytosolic calcium ion transport |
| response to chemokine |
| cellular response to chemokine |
| neutrophil migration |
| positive regulation of actin filament polymerization |
| activation of GTPase activity |
| positive regulation of endocytosis |
| regulation of receptor-mediated endocytosis |
| granulocyte migration |
| positive regulation of plasma membrane bounded cell projection assembly |
| regulation of leukocyte chemotaxis |
| regulation of cell-matrix adhesion |
| establishment of cell polarity |
| positive regulation of cell-substrate adhesion |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of sequestering of calcium ion |
| cell-matrix adhesion |
| myeloid leukocyte migration |
| positive regulation of protein polymerization |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| positive regulation of JNK cascade |
| positive regulation of lipid metabolic process |
| leukocyte chemotaxis |
| cell maturation |
| cellular response to interferon-gamma |
| positive regulation of protein kinase B signaling |
| regulation of actin filament polymerization |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| cellular response to interleukin-1 |
| negative regulation of cell-cell adhesion |
| negative regulation of cell projection organization |
| response to interferon-gamma |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| cell-substrate adhesion |
| regulation of JNK cascade |
| response to ketone |
| regulation of leukocyte migration |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| calcium ion transmembrane transport |
| response to interleukin-1 |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| positive regulation of T cell activation |
| regulation of endocytosis |
| cell chemotaxis |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of cell-substrate adhesion |
| regulation of chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of protein kinase B signaling |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| response to alcohol |
| regulation of stress-activated MAPK cascade |
| T cell activation |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| cell recognition |
| developmental maturation |
| cellular response to tumor necrosis factor |
| positive regulation of protein complex assembly |
| calcium ion transport |
| positive regulation of cell-cell adhesion |
| negative regulation of cell migration |
| regulation of actin filament organization |
| response to tumor necrosis factor |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| regulation of leukocyte cell-cell adhesion |
| divalent inorganic cation transport |
| negative regulation of cellular component movement |
| regulation of T cell activation |
| negative regulation of locomotion |
| regulation of cytosolic calcium ion concentration |
| regulation of actin cytoskeleton organization |
| response to acid chemical |
| regulation of supramolecular fiber organization |
| positive regulation of lymphocyte activation |
| regulation of cellular component size |
| leukocyte migration |
| positive regulation of cell projection organization |
| lymphocyte activation |
| regulation of actin filament-based process |
| regulation of lipid metabolic process |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| positive regulation of cell activation |
| cellular calcium ion homeostasis |
| negative regulation of immune system process |
| plasma membrane bounded cell projection assembly |
| calcium ion homeostasis |
| regulation of protein complex assembly |
| cell projection assembly |
| cellular divalent inorganic cation homeostasis |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| inflammatory response |
| positive regulation of cell migration |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of MAPK cascade |
| chemotaxis |
| regulation of vesicle-mediated transport |
| taxis |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cation transmembrane transport |
| positive regulation of organelle organization |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| regulation of cell activation |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| cation homeostasis |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| innate immune response |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of protein kinase activity |
| cation transport |
| regulation of cell migration |
| response to lipid |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| ion transmembrane transport |
| defense response to other organism |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| cell activation |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| transmembrane transport |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| LLY-284 2.6μM R06 exp291 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7723
- Expression level (log2 read counts): -7.68
Expression Distribution
CCL21 Expression in NALM6 Cells: -7.68
