CCL28

Entrez Summary: N/A
UniProt Summary: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.001μM R00 exp3	1.83
BAY-598 4μM R05 exp220	1.84

negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte adhesion to vascular endothelial cell
regulation of leukocyte tethering or rolling
negative regulation of cellular extravasation
regulation of leukocyte adhesion to vascular endothelial cell
regulation of cellular extravasation
negative regulation of leukocyte migration
chemokine activity
positive regulation of cell-matrix adhesion
cell
regulation of cell-matrix adhesion
positive regulation of cell-substrate adhesion
negative regulation of leukocyte cell-cell adhesion
negative regulation of cell-cell adhesion
regulation of leukocyte migration
cell chemotaxis
regulation of cell-substrate adhesion
response to nutrient
negative regulation of cell migration
negative regulation of cell adhesion
negative regulation of cell motility
positive regulation of cytosolic calcium ion concentration
regulation of leukocyte cell-cell adhesion
negative regulation of cellular component movement
negative regulation of locomotion
regulation of cytosolic calcium ion concentration
regulation of cell-cell adhesion
positive regulation of cell adhesion
cellular calcium ion homeostasis
negative regulation of immune system process
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
response to nutrient levels
response to extracellular stimulus
chemotaxis
taxis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis