CCL8
Gene Information
- Official Symbol: CCL8
- Official Name: C-C motif chemokine ligand 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 6355
- UniProt: P80075
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. {ECO:0000269|PubMed:9558113}.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| negative regulation by host of viral genome replication |
| phospholipase activator activity |
| negative regulation by host of viral process |
| modulation by host of viral genome replication |
| eosinophil chemotaxis |
| eosinophil migration |
| modulation by host of viral process |
| CCR chemokine receptor binding |
| monocyte chemotaxis |
| lymphocyte chemotaxis |
| mononuclear cell migration |
| chemokine activity |
| negative regulation of viral genome replication |
| lymphocyte migration |
| modification by host of symbiont morphology or physiology |
| interaction with symbiont |
| negative regulation of leukocyte proliferation |
| chemokine-mediated signaling pathway |
| cell |
| negative regulation of viral life cycle |
| neutrophil chemotaxis |
| granulocyte chemotaxis |
| response to chemokine |
| cellular response to chemokine |
| neutrophil migration |
| regulation of viral genome replication |
| negative regulation of viral process |
| granulocyte migration |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| leukocyte chemotaxis |
| regulation of viral life cycle |
| modification of morphology or physiology of other organism |
| cellular response to interferon-gamma |
| heparin binding |
| cellular response to interleukin-1 |
| response to interferon-gamma |
| regulation of leukocyte migration |
| response to interleukin-1 |
| regulation of viral process |
| cell chemotaxis |
| positive regulation of ERK1 and ERK2 cascade |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of leukocyte proliferation |
| protein kinase activity |
| cellular response to tumor necrosis factor |
| calcium ion transport |
| response to tumor necrosis factor |
| response to virus |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| divalent inorganic cation transport |
| leukocyte migration |
| positive regulation of GTPase activity |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| inflammatory response |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| innate immune response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| symbiotic process |
| ion homeostasis |
| exocytosis |
| interspecies interaction between organisms |
| cation transport |
| regulation of cell migration |
| cellular homeostasis |
| regulation of cell motility |
| defense response to other organism |
| cell migration |
| protein phosphorylation |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| export from cell |
| positive regulation of phosphorylation |
| cell motility |
| localization of cell |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18676
- Expression level (log2 read counts): -6.6
Expression Distribution
CCL8 Expression in NALM6 Cells: -6.6
