CCNB1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CCNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNB1
  * **<color #00a2e8>Official Name</color>**: cyclin B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=891|891]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14635|P14635]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123836|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin C|
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to DDT|
|histone H3-S10 phosphorylation involved in chromosome condensation|
|cellular response to iron(III) ion|
|cyclin B1-CDK1 complex|
|condensed nuclear chromosome outer kinetochore|
|regulation of chromosome condensation|
|histone kinase activity|
|histone H3-S10 phosphorylation|
|positive regulation of attachment of spindle microtubules to kinetochore|
|positive regulation of mitochondrial ATP synthesis coupled electron transport|
|response to iron(III) ion|
|regulation of mitochondrial ATP synthesis coupled electron transport|
|patched binding|
|positive regulation of histone phosphorylation|
|cyclin-dependent protein serine/threonine kinase activator activity|
|positive regulation of cellular respiration|
|positive regulation of oxidative phosphorylation|
|cellular response to iron ion|
|histone-serine phosphorylation|
|ventricular cardiac muscle cell development|
|positive regulation of mRNA 3-end processing|
|mitotic nuclear envelope disassembly|
|regulation of attachment of spindle microtubules to kinetochore|
|regulation of histone phosphorylation|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|regulation of spindle checkpoint|
|regulation of mitotic spindle checkpoint|
|ventricular cardiac muscle cell differentiation|
|nuclear envelope disassembly|
|membrane disassembly|
|response to insecticide|
|oocyte maturation|
|ubiquitin-like protein ligase binding|
|positive regulation of cardiac muscle cell proliferation|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of chromosome segregation|
|regulation of mRNA 3-end processing|
|histone phosphorylation|
|positive regulation of cell cycle G2/M phase transition|
|cyclin-dependent protein kinase holoenzyme complex|
|regulation of cellular respiration|
|regulation of oxidative phosphorylation|
|positive regulation of mRNA processing|
|regulation of cell cycle checkpoint|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of cardiac muscle tissue growth|
|response to iron ion|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|positive regulation of cyclin-dependent protein kinase activity|
|positive regulation of heart growth|
|oocyte development|
|regulation of cardiac muscle cell proliferation|
|chromosome condensation|
|oocyte differentiation|
|positive regulation of cardiac muscle tissue development|
|positive regulation of ATP metabolic process|
|mitotic metaphase plate congression|
|positive regulation of organ growth|
|positive regulation of fibroblast proliferation|
|regulation of mitotic metaphase/anaphase transition|
|nuclear envelope organization|
|regulation of metaphase/anaphase transition of cell cycle|
|metaphase plate congression|
|cellular response to fatty acid|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|regulation of mitotic sister chromatid separation|
|regulation of cardiac muscle tissue growth|
|cardiac muscle cell development|
|regulation of chromosome separation|
|tissue regeneration|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|regulation of heart growth|
|G1 DNA damage checkpoint|
|cardiac cell development|
|regulation of mitotic sister chromatid segregation|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|establishment of chromosome localization|
|chromosome localization|
|mitotic spindle organization|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of mRNA metabolic process|
|oogenesis|
|regulation of cardiac muscle tissue development|
|DNA damage response, signal transduction by p53 class mediator|
|regulation of sister chromatid segregation|
|positive regulation of cell cycle arrest|
|regulation of fibroblast proliferation|
|anaphase-promoting complex-dependent catabolic process|
|response to fatty acid|
|cardiac muscle cell differentiation|
|positive regulation of histone modification|
|positive regulation of cell cycle phase transition|
|regulation of organ growth|
|mitotic DNA damage checkpoint|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of chromosome segregation|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|microtubule cytoskeleton organization involved in mitosis|
|positive regulation of chromatin organization|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|mitotic sister chromatid segregation|
|cardiocyte differentiation|
|signal transduction by p53 class mediator|
|regulation of ATP metabolic process|
|spindle pole|
|female gamete generation|
|digestive tract development|
|G2/M transition of mitotic cell cycle|
|regulation of striated muscle tissue development|
|DNA damage checkpoint|
|cell cycle G2/M phase transition|
|nucleus organization|
|anatomical structure maturation|
|regulation of muscle tissue development|
|striated muscle cell development|
|regulation of muscle organ development|
|regulation of mRNA processing|
|sister chromatid segregation|
|digestive system development|
|DNA integrity checkpoint|
|mitotic nuclear division|
|regulation of histone modification|
|muscle cell development|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|spindle organization|
|regeneration|
|cell maturation|
|regulation of generation of precursor metabolites and energy|
|cardiac muscle tissue development|
|regulation of cell cycle G1/S phase transition|
|regulation of mitotic nuclear division|
|positive regulation of developmental growth|
|positive regulation of chromosome organization|
|peptidyl-serine phosphorylation|
|transcription initiation from RNA polymerase II promoter|
|DNA packaging|
|cellular response to hypoxia|
|regulation of chromatin organization|
|cellular response to metal ion|
|regulation of nuclear division|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|peptidyl-serine modification|
|striated muscle cell differentiation|
|cellular response to acid chemical|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|DNA-templated transcription, initiation|
|nuclear chromosome segregation|
|cellular response to inorganic substance|
|negative regulation of cell cycle phase transition|
|protein kinase activity|
|developmental maturation|
|muscle cell differentiation|
|germ cell development|
|positive regulation of growth|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|striated muscle tissue development|
|nuclear division|
|positive regulation of cell cycle process|
|muscle tissue development|
|DNA conformation change|
|negative regulation of mitotic cell cycle|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|response to hypoxia|
|response to acid chemical|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|establishment of organelle localization|
|histone modification|
|mitochondrial matrix|
|response to metal ion|
|covalent chromatin modification|
|in utero embryonic development|
|positive regulation of cell cycle|
|response to oxygen levels|
|developmental growth|
|growth|
|cellular component disassembly|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|protein kinase binding|
|microtubule cytoskeleton organization|
|muscle structure development|
|wound healing|
|transcription by RNA polymerase II|
|centrosome|
|cell division|
|response to toxic substance|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|heart development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|spermatogenesis|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|microtubule-based process|
|regulation of growth|
|mitotic cell cycle|
|protein catabolic process|
|gamete generation|
|chromatin organization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|membrane organization|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|multi-organism reproductive process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|cell development|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-3.39|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.88|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.49|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.43|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.39|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.34|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.3|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.26|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.26|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.25|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.18|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.06|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.04|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.02|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.99|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.96|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.95|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.87|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.83|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.81|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.73|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.72|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.83|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.86|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.91|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.98|
|[[:results:exp539|42°C R08 exp539]]|2.09|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.2|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.64|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.9|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fntb|FNTB]]|0.487|
|[[:human genes:z:zwilch|ZWILCH]]|0.486|
|[[:human genes:k:kntc1|KNTC1]]|0.471|
|[[:human genes:z:zw10|ZW10]]|0.459|
|[[:human genes:b:bub1b|BUB1B]]|0.44|
|[[:human genes:t:trip13|TRIP13]]|0.432|
|[[:human genes:e:esco2|ESCO2]]|0.43|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 154/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|4/28|
|bone|8/26|
|breast|6/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|2/21|
|liver|6/20|
|lung|19/75|
|lymphocyte|2/16|
|ovary|9/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3083
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNB1 Expression in NALM6 Cells: 7.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>