CCNC [The Human Chemical-Genetic Interaction Map Project]

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======= CCNC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNC
  * **<color #00a2e8>Official Name</color>**: cyclin C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=892|892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24863|P24863]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123838|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin-dependent protein serine/threonine kinase regulator activity|
|mediator complex|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription by RNA polymerase II|
|regulation of protein serine/threonine kinase activity|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.4|
|[[:results:exp303|39°C R06 exp303]]|-2.2|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.11|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.03|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.02|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.01|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.92|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.84|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.79|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.79|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.72|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.91|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.97|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.35|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.61|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.7|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|6.5|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|6.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13|MED13]]|0.591|
|[[:human genes:c:casp3|CASP3]]|0.56|
|[[:human genes:f:fnip1|FNIP1]]|0.527|
|[[:human genes:m:med13l|MED13L]]|0.508|
|[[:human genes:c:casp8|CASP8]]|0.489|
|[[:human genes:f:flcn|FLCN]]|0.47|
|[[:human genes:z:zc3h18|ZC3H18]]|0.467|
|[[:human genes:c:cxorf38|CXorf38]]|0.46|
|[[:human genes:h:hdac8|HDAC8]]|0.447|
|[[:human genes:u:ube3a|UBE3A]]|0.445|
|[[:human genes:f:fadd|FADD]]|0.443|
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.442|
|[[:human genes:c:clk3|CLK3]]|0.44|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.432|
|[[:human genes:p:ppig|PPIG]]|0.43|
|[[:human genes:z:zdhhc20|ZDHHC20]]|0.419|
|[[:human genes:l:lsm12|LSM12]]|0.417|
|[[:human genes:h:hnrnpl|HNRNPL]]|0.405|
|[[:human genes:p:prr12|PRR12]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNC Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>