CCNC

Gene Information

Official Symbol: CCNC
Official Name: cyclin C
Aliases and Previous Symbols: N/A
Entrez ID: 892
UniProt: P24863
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 1μM R03 exp100	-2.4
39°C R06 exp303	-2.2
FTY720 3μM R08 exp483	-2.11
Nutlin-3A 1.6μM R06 exp294	-2.03
Nicotinamide 2000μM R01 exp50	-2.02
HMS-I1 1μM R01 exp46	-2.01
Hippuristanol 0.12μM R08 exp488	-1.92
Latrunculin-B 10μM R07 exp374	-1.84
Rucaparib 6.5μM R08 exp520	-1.79
Trimetrexate 0.03μM R08 exp535	-1.79
Dimethyloxaloylglycine 100μM R05 exp229	-1.72
CR131-b 0.005μM R08 exp474	1.91
Oligomycin-A 20μM R00 exp26	1.97
Aminopterin 0.005μM R07 exp335	2.35
Bortezomib 0.005μM R00 exp6	2.61
3-Bromopyruvate 7μM R04 exp175	2.7
TRAIL 5ng/ml R00 exp35	6.5
TRAIL 50ng/ml R00 exp36	6.56

Gene	Correlation
MED13	0.591
CASP3	0.56
FNIP1	0.527
MED13L	0.508
CASP8	0.489
FLCN	0.47
ZC3H18	0.467
CXorf38	0.46
HDAC8	0.447
UBE3A	0.445
FADD	0.443
TNFRSF10B	0.442
CLK3	0.44
KHDRBS1	0.432
PPIG	0.43
ZDHHC20	0.419
LSM12	0.417
HNRNPL	0.405
PRR12	0.403

Global Fraction of Cell Lines Where Essential: 11/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2026
Expression level (log2 read counts): 6.29

Expression Distribution

cyclin-dependent protein serine/threonine kinase regulator activity
mediator complex
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
transcription by RNA polymerase II
regulation of protein serine/threonine kinase activity
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
regulation of protein phosphorylation
positive regulation of transcription, DNA-templated
regulation of phosphorylation
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process